2018 Top Ten Finalists
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This year, the level of scientific rigor, quality, and innovation in all of the nominated studies was truly outstanding.  The Clinical Research Forum congratulates the following studies who were finalists: 

 

30 Day Readmission and Association with Changes in Mortality in Heart Failure

Gregg Fonarow, MD,  UCLA

Journal Citation:  Association of the Hospital Readmissions Reduction Program Implementation With Readmission and Mortality Outcomes in Heart Failure; Ankur Gupta, MD, PhD; Larry A. Allen, MD, MHS; Deepak L. Bhatt, MD, MPH; Margueritte Cox, MS, MGIST; Adam D. DeVore, MD, MHS; Paul A. Heidenreich, MD, MS; Adrian F. Hernandez, MD, MHS; Eric D. Peterson, MD, MPH; Roland A. Matsouaka, PhD; Clyde W. Yancy, MD, MSc,; Gregg C. Fonarow, MD, 9 JAMA Cardiol. 2018;3(1):44-53. doi:10.1001/jamacardio.2017.4265

 

Advance forecasting of seasonal influenza A (H3N2)

Mercedes Pascual, University of Chicago

Journal Citation: Evolution-informed forecasting of seasonal influenza A (H3N2); Xiangjun Du, Aaron A. King, Robert J. Woods, Mercedes Pascual Evolution-informed forecasting of seasonal influenza A (H3N2) Science Translational Medicine 2017; 9[413]: eaan5325.  DOI: 10.1126/scitranslmed.aan5325.

 

An Etiology-Based Reclassification of Diseases

Andrey Rzhetsky, University of Chicago

Journal Citation: Classification of common human diseases derived from shared genetic and environmental determinants; Kanix Wang, Hallie Gaitsch, Hoifung Poon, Nancy J Cox, Andrey Rzhetsky Classification of common human diseases derived from shared genetic and environmental determinants Nature Genetics 2017; 49[9]:1319-25; doi:10.1038/ng.3931

 

Development of Cardiovascular Risk Prediction Models With Neighborhood Socioeconomic Position Data

Jarrod Dalton, Cleveland Clinic and Case Western University

Journal Citation: Accuracy of Cardiovascular Risk Prediction Varies by Neighborhood Socioeconomic Position: A retrospective Cohort Study; Dalton JD, Perzynski AT, Zidar DA, Rothberg MB, Coulton CJ, Milinovich AT, Einstadter D, Karichu JK, Dawson NV. Ann Intern Med  2017;167:456-464

 

Dose of physical activity, physical functioning and disability risk in mobility limited older adults

Roger A. Fielding, PhD, Tufts University

Journal Citation: Dose of physical activity, physical functioning and disability risk in mobility limited older adults: Results from the LIFE study randomized trial; Fielding, Roger A., Jack M. Guralnik, Abby C. King, Marco Pahor, Mary M. McDermott, Catrine Tudor-Locke, Todd M. Manini et al. "Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial." PloS one 12, no. 8 (2017): e0182155.

 

Meta-Analyses of Glucose and Insulin-related traits Consortium

Aaron Leong, Massachusetts General Hospital

Journal Citation: Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis; Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, Chu AY, Zhang W, Wang X, Chen P, Maruthur NM, Porneala BC, Sharp SJ, Jia Y, Kabagambe EK, Chang LC, Chen WM, Elks CE, Evans DS, Fan Q, Giulianini F, Go MJ, Hottenga JJ, Hu Y, Jackson AU, Kanoni S, Kim YJ, Kleber ME, Ladenvall C, Lecoeur C, Lim SH, Lu Y, Mahajan A, Marzi C, Nalls MA, Navarro P, Nolte IM, Rose LM, Rybin DV, Sanna S, Shi Y, Stram DO, Takeuchi F, Tan SP, van der Most PJ, Van Vliet-Ostaptchouk JV, Wong A, Yengo L, Zhao W, Goel A, Martinez Larrad MT, Radke D, Salo P, Tanaka T, van Iperen EPA, Abecasis G, Afaq S, Alizadeh BZ, Bertoni AG, Bonnefond A, Battcher Y, Bottinger EP, Campbell H, Carlson OD, Chen CH, Cho YS, Garvey WT, Gieger C, Goodarzi MO, Grallert H, Hamsten A, Hartman CA, Herder C, Hsiung CA, Huang J, Igase M, Isono M, Katsuya T, Khor CC, Kiess W, Kohara K, Kovacs P, Lee J, Lee WJ, Lehne B, Li H, Liu J, Lobbens S, Luan J, Lyssenko V, Meitinger T, Miki T, Miljkovic I, Moon S, Mulas A, MÃller G, Maller-Nurasyid M, Nagaraja R, Nauck M, Pankow JS, Polasek O, Prokopenko I, Ramos PS, Rasmussen-Torvik L, Rathmann W, Rich SS, Robertson NR, Roden M, Roussel R, Rudan I, Scott RA, Scott WR, Sennblad B, Siscovick DS, Strauch K, Sun L, Swertz M, Tajuddin SM, Taylor KD, Teo YY, Tham YC, TÃnjes A, Wareham NJ, Willemsen G, Wilsgaard T, Hingorani AD; EPIC-CVD Consortium; EPIC-InterAct Consortium; Lifelines Cohort Study, Egan J, Ferrucci L, Hovingh GK, Jula A, Kivimaki M, Kumari M, Njølstad I, Palmer CNA, Serrano Ríos M, Stumvoll M, Watkins H, Aung T, BlÃher M, Boehnke M, Boomsma DI, Bornstein SR, Chambers JC, Chasman DI, Chen YI, Chen YT, Cheng CY, Cucca F, de Geus EJC, Deloukas P, Evans MK, Fornage M, Friedlander Y, Froguel P, Groop L, Gross MD, Harris TB, Hayward C, Heng CK, Ingelsson E, Kato N, Kim BJ, Koh WP, Kooner JS, KÃrner A, Kuh D, Kuusisto J, Laakso M, Lin X, Liu Y, Loos RJF, Magnusson PKE, März W, McCarthy MI, Oldehinkel AJ, Ong KK, Pedersen NL, Pereira MA, Peters A, Ridker PM, Sabanayagam C, Sale M, Saleheen D, Saltevo J, Schwarz PE, Sheu WHH, Snieder H, Spector TD, Tabara Y, Tuomilehto J, van Dam RM, Wilson JG, Wilson JF, Wolffenbuttel BHR, Wong TY, Wu JY, Yuan JM, Zonderman AB, Soranzo N, Guo X, Roberts DJ, Florez JC, Sladek R, Dupuis J, Morris AP, Tai ES, Selvin E, Rotter JI, Langenberg C, Barroso I, Meigs JB. PLoS Med. 2017 Sep 12;14(9):e1002383. doi: 10.1371/journal.pmed.1002383. eCollection 2017 Sep. PMID: 28898252

 

Patient-hospital Microbiome Interactions

Jack Gilbert, University of Chicago

Journal Citation: Bacterial colonization and succession in a newly opened hospital; Simon Lax, Naseer Sangwan, Daniel Smith, Peter Larsen, Kim M. Handley, Miles Richardson, Kristina Guyton, Monika Krezalek, Benjamin D. Shogan, Jennifer Defazio, Irma Flemming, Baddr Shakhsheer, Stephen Weber, Emily Landon, Sylvia Garcia-Houchins, Jeffrey Siegel, John Alverdy, Rob Knight, Brent Stephens, Jack A. Gilbert Bacterial colonization and succession in a newly opened hospital Science Translational Medicine 2017; 9[391]:eaah6500

 

Pediatric Exoskeleton to Enhance and Maintain Mobility in Cerebral Palsy and Other Neurological Disorders

Tom Bulea, National Institutes of Health

Journal Citation: A lower-extremity exoskeleton improves knee extension in children with crouch gait from cerebral palsy; Lerner, Z.F., Damiano, D.L., & Bulea, T.C. (2017). A lower-extremity exoskeleton improves knee extension in children with crouch gait from cerebral palsy. Science Translational Medicine, 9(404), eeam9145.

 

Queens Library HealthLink

Bruce David Rapkin, Albert Einstein College of Medicine

Journal Citation: Reducing Disparities in Cancer Screening and Prevention through Community Based Participatory Research Partnerships with Local Libraries: A Comprehensive Dynamic Trial; Rapkin BD, Weiss E, Lounsbury D, Michel T, Gordon A, Erb Downward J, Sabino⠐Laughlin E, Carpenter A, Schwartz CE, Bulone L, Kemeny M. Reducing Disparities in Cancer Screening and Prevention through Community Based Participatory Research Partnerships with Local Libraries: A Comprehensive Dynamic Trial. American journal of community psychology. 2017 Sep 1;60(1-2):145-59.